Andrea Martin to spice up Best Medicine season 2 as feisty guest: exclusive

Veteran comic actress Andrea Martin is joining the cast of Best Medicine for an episode in Season 2, bringing her trademark mischief to the small Maine town at the center of the series. The guest turn promises sparks with established characters and raises stakes for the community when the newcomer’s habits threaten more than just local nerves.

Martin will portray **Judith**, a quirky acquaintance of **Aunt Sarah** (played by Annie Potts), whose personal choices escalate into a townwide problem that forces Sarah and other residents to step in.

What to expect from the episode

The appearance is billed as a character-driven installment that leans on comic tension: Judith’s smoking habit becomes a public-safety concern rather than a private foible, creating both conflict and darkly humorous moments.

  • Actor: Andrea Martin
  • Role: Judith, a longtime friend of Aunt Sarah
  • Conflict: Personal behavior that endangers local safety
  • Impact: Forces central characters to intervene, setting up emotional and comedic beats
  • Network: Fox, Season 2 of Best Medicine

Showrunner Liz Tuccillo described the day Martin filmed opposite Potts and series regular Didi Cohn as an unforgettable set moment, noting how their chemistry elevated the scene. The creative team had been eager to work with Martin after she reached out to express admiration for the show and a fondness for Maine — even joking about wanting a local role such as a librarian — and the producers eventually found the right part to bring her in.

Martin’s casting signals more than a one-off cameo: her presence injects veteran comedic timing and unpredictable energy into the show’s ensemble, likely giving Season 2 a memorable episode that fans will discuss. For viewers, it’s a chance to see how a small-town series balances humor with community-level consequences.

Expect the guest appearance to arrive in an upcoming episode during Season 2; the creative team suggests the storyline will blend character comedy with tangible stakes for Port Wenn residents. For now, the addition of Andrea Martin adds a high-profile, character-driven wrinkle to a season already building momentum.

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